Top Recruiting Trials
20 actively recruiting studies
A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)
Biogen
n=30
Ann and Robert H Lurie Childrens Hospital of Chicago
Chicago, Illinois
Intervention DRUG: Salanersen — Administered intrathecally
Eligibility Ages 0 Days – 42 Days
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
National Institute of Mental Health (NIMH)
n=184
National Institutes of Health Clinical Center
Bethesda, Maryland
Intervention DRUG: 11C-MC1 — Injected IV followed by PET scanning
Eligibility Ages 18 Years – 99 Years
Augmented Reality BCI Longitudinal Study for Persons With Late Stage ALS
Cognixion
n=10
Cognixion
Santa Barbara, California
Intervention DEVICE: Cognixion ONE — A wearable augmented reality brain computer interface with self contained computer and software to enable communication ...
Eligibility Ages 18 Years
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
Nader Pouratian
n=2
UT Southwestern Medical Center
Dallas, Texas
Intervention DEVICE: Mind Extender (MindEx) — NeuroPort Multi-Port Arrays allow for the local recording of cerebral cortex. The Mind Extender (MindEx) system is prima...
Eligibility Ages 18 Years – 65 Years
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Chulalongkorn University
n=100
King Chulalongkorn Memorial hospital, The Thai Red Cross Society
Bangkok, Pathumwan
Intervention DEVICE: Personalized rTMS — Personalized repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise
Eligibility Ages 18 Years – 80 Years
Cardiopulmonary Exercise Testing and Oscillometry for the Evaluation of Dyspnea
University of Rochester
n=50
Highland Hospital
Rochester, New York
Intervention DEVICE: Oscillometer — The tremoFlo C-100 Airwave Oscillometry System is intended to measure respiratory system impedance using the Forced Osci...
Eligibility Ages 18 Years
Comprehensive Assessment of Neurodegeneration and Dementia
McGill University
n=1573
University of Calgary
Calgary, Alberta
Eligibility Ages 50 Years – 90 Years
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Johns Hopkins University
n=50
Johns Hopkins Hospital
Baltimore, Maryland
Eligibility Ages 18 Years – 90 Years
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
Ricard Mellado Artigas
n=120
Hospital Clínic de Barcelona
Barcelona, Barcelona
Intervention DEVICE: CPAP — 12 cmH2O for 48 hours (at least 10 hours of therapy per day). Nasobucal interface will be the preferred route with compl...
Eligibility Ages 18 Years – 80 Years
Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
University of California, Irvine
n=50
University of California, Irvine
Irvine, California
Eligibility Ages 18 Years
Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure
South West Sydney Local Health District
n=70
Intensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District
Liverpool, New South Wales
Intervention DRUG: Alteplase — The enzyme tissue plasminogen activator that cleaves plasminogen to form plasmin.
Eligibility Ages 18 Years – 75 Years
Role of HFNC During FOB in Patients With Respiratory Failure
Mansoura University
n=60
Faculty of Medicine, Mansoura University
Al Mansurah, Dakahlia Governorate
Intervention DEVICE: High flow nasal canula — High-flow nasal cannula (HFNC) oxygen therapy will be administered using the Vapotherm Precision Flow Hi-VNI system. HFN...
Eligibility Ages 18 Years
the Effect of Adult Intubated Patient Clinical Pathway on Post-extubation Complications Prevention
Damanhour University
n=80
Faculty of Nursing, Damanhour University
Damanhūr, Egypt
Intervention COMBINATION_PRODUCT: ETT cuff pressure monitoring, ETT suctioning, cough augmentation technique, swallowing exercises,: Nebulized budesonide 1mg and IV methylprednisolone 40 mg we — cough augmentation, larson maneuver, swallowing rehabilitation
Eligibility Ages 18 Years – 60 Years
CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
Neuralink Corp
n=6
University Health Network
Toronto, Ontario
Intervention DEVICE: N1 Implant — The N1 Implant is a type of implantable brain-computer interface.
Eligibility Ages 19 Years
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
Peter C. Gerszten, MD
n=15
University of Pittsburgh
Pittsburgh, Pennsylvania
Intervention DEVICE: Bipolar Neural Stimulation Electrode — All individuals enrolled in this study will receive electrical stimulation to the dorsal cervical spinal nerves using th...
Eligibility Ages 21 Years – 75 Years
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
Duke University
n=75
Duke University Health System
Durham, North Carolina
Intervention BEHAVIORAL: Cardiac point-of-care ultrasound (POCUS) training and clinical pathway — Participants will complete a cardiac POCUS simulation session and a hands-on observed structured clinical skill exam (OS...
Eligibility Ages 18 Years
Barrett's Esophagus Related Neoplasia (BERN) Project
Midwest Biomedical Research
n=150
Kansas city VA Medical center
Kansas City, Missouri
Eligibility Ages 18 Years
Dissemination and Implementation of DIGEST™ as an Evidence-based Measurement Tool for Dysphagia: A Randomized Implementation Trial
M.D. Anderson Cancer Center
n=85
MD Anderson Cancer Center
Houston, Texas
Intervention OTHER: No intervention — receive no active implementation
Eligibility Ages 18 Years
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Imperial College London
n=700
Imperial College London
London
Intervention DIAGNOSTIC_TEST: MRI brain, Blood tests, cognitive assessments — observational study examining cognition post stroke using behavioural tests, MRI brain and blood tests
Eligibility Ages 18 Years
Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
n=900
National Institutes of Health Clinical Center
Bethesda, Maryland
Eligibility Ages 1 Day – 120 Years