TrialFinder  /  Landscape Report BIPOLAR DISORDER  ·  2026-10-26 Revasser  /  revasserkernel.com
Landscape Report TrialFinder
SOURCE  ClinicalTrials.gov API v2
GENERATED  2026-10-26
VERSION  v1
SAMPLE  100 of 4277 studies

bipolar disorder

The bipolar disorder clinical trial landscape includes 4277 actively recruiting trials. Semantic expansion identified 4063 additional trials beyond exact-match search, representing a 1898.6% discovery lift across related conditions and therapeutic approaches.

Recruiting
4277
active trials
Expansion Lift
+1898.6%
4063 additional trials
Top Sponsor
VA Office of Research and Development
3 trials
Dominant Phase
NA
53 of 103 sampled
Pipeline Overview
Phase Distribution
NA
53
Early I
1
Phase 1
1
Phase 2
9
Phase 3
9
Phase 4
4
Other
26
Therapeutic Modalities
BEHAVIORAL
61
DRUG
45
OTHER
35
DEVICE
20
PROCEDURE
10
BIOLOGICAL
4
DIETARY_SUPPLEMENT
3
DIAGNOSTIC_TEST
1
Recruiting vs. Completed (2yr)
Recruiting
4277
Completed
3111
Competitive Landscape
Sponsor Classification
13%
79%
4%
4%
FED (3)
OTHER (19)
OTHER_GOV (1)
NETWORK (1)
Top Sponsors
SponsorTrialsClass
VA Office of Research and Development3FED
The University of Texas Health Science Center, Houston3OTHER
Mayo Clinic2OTHER
Dr. Inge Winter2OTHER
Haukeland University Hospital2OTHER
Assistance Publique - Hôpitaux de Paris2OTHER
Stanford University2OTHER
Henan Cancer Hospital1OTHER_GOV
South Valley University1OTHER
Brooklyn Clinical Research1NETWORK
Ardahan University1OTHER
Lishu Gao1OTHER
Philipps University Marburg1OTHER
University of Aarhus1OTHER
University Ghent1OTHER
Geographic Distribution
Top U.S. States by Trial Density
StateTrialsTop City
California20Los Angeles
Texas15Houston
New York14New York
Florida12Orlando
New Jersey7Marlton
Massachusetts5Boston
Alabama4Birmingham
Minnesota3Rochester
North Carolina3Salisbury
Pennsylvania3Philadelphia
Ohio3Cleveland
Louisiana3New Orleans
Oregon3Portland
Washington3Seattle
South Carolina2Charleston
Arizona2Scottsdale
Iowa2Iowa City
Georgia2Atlanta
Oklahoma2Edmond
Tennessee2Memphis
Expansion Intelligence
+1898.6%
Discovery lift — trials found by semantic expansion that exact-match search misses entirely. This is the gap competitors don't see.
4
Exact
2
Parent
5
Related
5
Comorbid
6
Therapeutic
Top Expansion Terms
  • mood disorder Parent
  • affective disorder Parent
  • cyclothymia Related
  • schizoaffective disorder Related
  • mood episode Related
  • mania Related
  • hypomania Related
  • anxiety Comorbid
  • substance use disorder Comorbid
  • metabolic syndrome Comorbid

These terms are curated from clinical literature — not generated by a language model. Each captures trials that use variant nomenclature for the same underlying condition or therapeutic area.

Key Findings
What This Landscape Means for bipolar disorder
high
Standard searches miss 1899% of relevant trials for bipolar disorder — semantic expansion across related conditions and therapeutic approaches is essential for complete landscape visibility.
4063 additional trials found via expansion vs 214 exact matches
high
9 Phase 3 trials indicate a maturing pipeline with near-term approval potential.
Phase 3 represents 9% of sampled trials
Next Steps
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Top Recruiting Trials
20 actively recruiting studies
Long-term Follow-up of Anxiety and Depression in Patients With Malignant Tumors
Henan Cancer Hospital n=200 Department of Bone and Soft Tissue ,Henan Cancer Hospital Zhengzhou, Henan
Intervention OTHER: Hospital Anxiety and Depression Scale — The basic information, anxiety and depression, treatment and prognosis of these patients were collected.
Contact Wang Jiaqiang, Dr · 13592413731 · wjqwtj@126.com
Bipolar Resection vs Enucleation of Prostate
South Valley University n=100 Faculty of Medicine South Valley University Qina, Qena Governorate
Intervention PROCEDURE: TURP — Using bipolar loop diathermy via cystoscopy, excess prostate tissue is resected piecemeal to remove obstruction to the p...
Eligibility Ages 50 Years – 80 Years, MALE only
Contact AHMED A.FATAH HAMED, Master's · 00201146085302 · ahmeda.hamed1991@med.svu.edu.eg
Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility
Brooklyn Clinical Research n=10000 Brooklyn Clinical Research Brooklyn, New York
Intervention OTHER: Blood work — Blood work on some participants to review eligibility for future clinical trials
Eligibility Ages 18 Years
Contact Ammara Mushtaq, MD · 929-203-5879 · amushtaq@brooklynclinicalresearch.com
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Mayo Clinic n=200 Mayo Clinic Rochester, Minnesota
Intervention OTHER: Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels. — Functional near-infrared spectroscopy (fNIRS) transcutaneously measures changes in oxyhemoglobin in the prefrontal corte...
Eligibility Ages 18 Years
Contact Sarah M. Williams · 507-422-2972 · Williams.Sarah2@mayo.edu
The Effect of Lavender Inhalation on Anxiety, Sleep, and Blood Pressure
Ardahan University n=50 Ardahan State Hospital Ardahan, Ardahan
Intervention OTHER: Lavender — Participants receive lavender oil inhalation three times per week for one month (total of 12 sessions) using a standardi...
Contact Derya ŞİMŞEKLİ, PhD · +905545965789 · deryasimsekli@ardahan.edu.tr
Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging Mechanisms
Lishu Gao n=123 Affiliated Hangzhou First People's Hospital Hangzhou, Zhejiang
Intervention PROCEDURE: Electroacupuncture (EA) — Electroacupuncture (EA) is performed at acupoints including GV20 (Baihui), EX-HN1 (Sishencong), GV29 (Shenting), EX-HN16...
Eligibility Ages 18 Years – 60 Years
Contact Lishu Gao · +86 13858015836 · rodelo@sina.com
Enhancing Generalization of Virtual Reality Exposure for Public Speaking Anxiety
Philipps University Marburg n=48 Department of Psychology, Philipps-University of Marburg Marburg, Hesse
Intervention BEHAVIORAL: VR Exposure — 6 VR speech exposure trials (3 min each; topic: "something you are proud of")
Eligibility Ages 18 Years – 70 Years
Contact Christoph Benke, Ph.D. · +49 6421 28-24091 · christoph.benke@uni-marburg.de
NCT05973851 PHASE3
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Dr. Inge Winter n=418 Medical University Innsbruck Innsbruck
Intervention DRUG: Esketamine Nasal Product — See arm description
Eligibility Ages 18 Years – 65 Years
Contact Inge Winter, Dr. · +31875553227 · i.winter@umcutrecht.nl
NCT04932577 PHASE2, PHASE3
Faecal Microbiota Transplantation for Liver Cirrhosis
University of Aarhus n=220 Department of Hepatology and Gastroenterology, Aarhus University Hospital Aarhus
Intervention BIOLOGICAL: Faecal microbiota transplantation — All participant will receive three applications of either FMT or placebo and afterwards followed for 1 year.
Eligibility Ages 18 Years – 75 Years
Contact Karen Louise Thomsen, PhD · +4526949260 · karethom@rm.dk
NCT03642028 PHASE4
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress
VA Office of Research and Development n=190 VA Long Beach Healthcare System, Long Beach, CA Long Beach, California
Intervention DRUG: Suvorexant — Suvorexant, a dual orexin receptor antagonist, is the first in a new class of drugs with great promise of addressing ins...
Eligibility Ages 18 Years – 75 Years
Contact Sabra S Inslicht, PhD · (415) 221-4810 · sabra.inslicht@va.gov
Co-creation of Tools for Children and Adolescents with Suicidal Thoughts And/or Behaviour
University Ghent n=30 Flemish Centre of Expertise in Suicide Prevention, Ghent University Ghent
Intervention OTHER: Tools — In the co-creation meetings, developed tools will be presented. Participants will be asked to provide feedback and input...
Eligibility Ages 10 Years – 18 Years
Contact Eva De Jaegere, PhD · +32 9 332.07.75 · eva.dejaegere@ugent.be
Pilot Study of Virtual Reality Therapy for Students With Anxiety
The University of Texas Health Science Center, Houston n=100 The University of Texas Health Science Center at Houston Houston, Texas
Intervention DEVICE: gameChange — Staff will explain the rationale behind gameChange, and briefly explain the different scenarios: a doctor's office, a wa...
Eligibility Ages 18 Years – 30 Years
Contact Tsai Jack, PhD · 210-276-9022 · Jack.Tsai@uth.tmc.edu
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
I.M. Sechenov First Moscow State Medical University n=40 Moscow Moscow
Intervention DRUG: Rifaximin — Rifaximin (Alfa Normix®, Alfa Wassermann S.P.A., Italy, registration number LS-001993, 08/31/2010) in standard doses of ...
Eligibility Ages 18 Years – 80 Years
Contact Konstantin Ivashkin · +7 926 213 58 33 · ivashkin_k_v@staff.sechenov.ru
Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes
West Kazakhstan Marat Ospanov Medical University n=310 Outpatient clinics of Aktobe region, West Kazakhstan Marat Ospanov Medical University Aktobe, Aktobe
Eligibility Ages 18 Years – 74 Years
Contact Mengtay S Makashova · +77058440060 · ersultanbeknur@gmail.com
App-Based Optimization of Long-Term CPAP Adherence and Quality of Life
Mayo Clinic n=40 Mayo Clinic in Arizona Scottsdale, Arizona
Intervention BEHAVIORAL: SleepWell24 Application — The SleepWell24 application will use connections with a Shelly smart plug and a Fitbit Charge 4 along with weekly questi...
Eligibility Ages 18 Years
Contact Timothy Morgenthaler, MD · Mayo Clinic
Sleep and Circadian Interventions for College Students at High Risk of Suicide
University of Pittsburgh n=90 Western Psychiatric Hospital/University of Pittsburgh Pittsburgh, Pennsylvania
Intervention BEHAVIORAL: Sleep Feedback + Psychoeducation — Participants are provided with an actigraphy watch that is used to monitor their sleep and activity throughout the day a...
Eligibility Ages 18 Years – 25 Years
Contact Dawn Rice, MS · 412-297-1947 · ricedm@upmc.edu
The Effect of Spinal Cord Stimulators on Restless Leg Syndrome
University of Alabama at Birmingham n=50 University of Alabama at Birmingham Birmingham, Alabama
Intervention OTHER: H-Reflex — H-reflex - A small electrical stimulus is provided to the leg and foot area and a measurement of the stimulus is taken b...
Eligibility Ages 18 Years
Contact Marshall Holland, MD · 2059343411 · mtholland@uabmc.edu
NCT05603104 PHASE3
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
Dr. Inge Winter n=1254 Sheba Medical Center Ramat Gan
Intervention DRUG: Clozapine — See arm description
Eligibility Ages 18 Years – 70 Years
Contact Inge Winter, Dr. · +31875553227 · i.winter@umcutrecht.nl
Developing Resilience and Anxiety Management Through the Arts
Case Western Reserve University n=110 Case Western Reserve University Cleveland, Ohio
Intervention BEHAVIORAL: Improvisation + Wellness — Theatrical improvisation exercises, the theatrical art of performance and storytelling without a script, will be combine...
Eligibility Ages 8 Years – 17 Years
Contact Amy Przeworski, PhD · 216-368-5021 · axp335@case.edu
Triage Survey for Psychiatry Research Eligibility
Adams Clinical n=20000 Adams Clinical, Boston Boston, Massachusetts
Intervention OTHER: Survey — Participants will be surveyed on demographics, medical history, and current psychiatric symptoms. Vital signs, urine dru...
Eligibility Ages 18 Years
Contact Miriam Evans, PhD · 617-744-8542 · mevans@adamsclinical.com