TrialFinder  /  Landscape Report CEREBELLAR COGNITIVE AFFECTIVE SYNDROME  ·  2026-09-02 Revasser  /  revasserkernel.com
Landscape Report TrialFinder
SOURCE  ClinicalTrials.gov API v2
GENERATED  2026-09-02
VERSION  v1
SAMPLE  100 of 303 studies

cerebellar cognitive affective syndrome

The cerebellar cognitive affective syndrome clinical trial landscape includes 303 actively recruiting trials. Semantic expansion identified 301 additional trials beyond exact-match search, representing a 15050% discovery lift across related conditions and therapeutic approaches.

Recruiting
303
active trials
Expansion Lift
+15050%
301 additional trials
Top Sponsor
VA Office of Research and Development
3 trials
Dominant Phase
NA
63 of 105 sampled
Pipeline Overview
Phase Distribution
NA
63
Early I
1
Phase 1
10
Phase 2
8
Phase 3
2
Other
21
Therapeutic Modalities
DEVICE
56
BEHAVIORAL
45
OTHER
32
DRUG
26
PROCEDURE
12
BIOLOGICAL
1
COMBINATION_PRODUCT
1
DIAGNOSTIC_TEST
1
Recruiting vs. Completed (2yr)
Recruiting
303
Completed
140
Competitive Landscape
Sponsor Classification
9%
9%
81%
FED (3)
INDUSTRY (3)
OTHER (26)
Top Sponsors
SponsorTrialsClass
VA Office of Research and Development3FED
Biogen3INDUSTRY
Fondazione Don Carlo Gnocchi ETS2OTHER
The Cleveland Clinic2OTHER
Chang Gung University2OTHER
Johns Hopkins University2OTHER
University of Texas Southwestern Medical Center2OTHER
University of Illinois at Chicago2OTHER
Weill Medical College of Cornell University2OTHER
IRCCS Eugenio Medea2OTHER
I.R.C.C.S. Fondazione Santa Lucia2OTHER
University of Pennsylvania2OTHER
Istituti Clinici Scientifici Maugeri SpA2OTHER
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.2OTHER
Federal University of Paraíba2OTHER
Geographic Distribution
Top U.S. States by Trial Density
StateTrialsTop City
Texas14Dallas
Florida14Gainesville
California10Los Angeles
Pennsylvania9Philadelphia
Maryland8Baltimore
New York8New York
Ohio7Cleveland
Tennessee7Memphis
Illinois5Chicago
Massachusetts5Boston
Minnesota5Rochester
Colorado4Aurora
New Jersey4East Brunswick
Utah3Salt Lake City
Virginia3Fairfax
Missouri3St Louis
New Mexico3Albuquerque
North Carolina2Morrisville
Alabama2Birmingham
Indiana2Indianapolis
Expansion Intelligence
+15050%
Discovery lift — trials found by semantic expansion that exact-match search misses entirely. This is the gap competitors don't see.
3
Exact
1
Parent
2
Region
3
Related
3
Comorbid
3
Therapeutic
Top Expansion Terms
  • cerebellar disorder Parent
  • cerebellar Region
  • posterior fossa Region
  • cerebellar ataxia Related
  • cerebellar mutism Related
  • posterior fossa syndrome Related
  • executive dysfunction Comorbid
  • visuospatial impairment Comorbid
  • affect dysregulation Comorbid
  • cerebellar stimulation Therapeutic

These terms are curated from clinical literature — not generated by a language model. Each captures trials that use variant nomenclature for the same underlying condition or therapeutic area.

Key Findings
What This Landscape Means for cerebellar cognitive affective syndrome
high
Standard searches miss 15050% of relevant trials for cerebellar cognitive affective syndrome — semantic expansion across related conditions and therapeutic approaches is essential for complete landscape visibility.
301 additional trials found via expansion vs 2 exact matches
high
Phase 2 volume (8) significantly exceeds Phase 3 (2), indicating a pipeline bottleneck — most candidates are 2-4 years from potential approval.
Phase 2/Phase 3 ratio: 4.0x
Next Steps
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Top Recruiting Trials
20 actively recruiting studies
Outcomes of ICT Assistive Technology in RehabiliTAtIoN Pathways
Fondazione Don Carlo Gnocchi ETS n=50 IRCCS Fondazione Don Carlo Gnocchi ONLUS Milan, MI
Intervention OTHER: scales and questionnaire administration — evaluation of the quality of prosthetic intervention, verification of the adequacy of assistive devices, and outcomes me...
Contact Claudia Salatino · +39-0240308283 · csalatino@dongnocchi.it
Hong Kong Spinocerebellar Ataxias Registry
Chinese University of Hong Kong n=300 Prince of Wales Hospital Hong Kong, Shatin
Intervention OTHER: no intervention — No intervention but clinical assessement for all recruited subjects
Eligibility Ages 18 Years – 90 Years
Contact Anne YY CHAN · (852) 3505 1855 · yychananne@gmail.com
Efficacy of Low-intensity Shockwave vs Radial Wave for Treatment of Erectile Dysfunction and Pelvic Pain
The Cleveland Clinic n=186 Cleveland Clinic Foundation Cleveland, Ohio
Intervention DEVICE: Focused shockwave — Storz Duolith SD-1 (Storz Medical, Tagerwilen, Switzerland)
Eligibility Ages 40 Years, MALE only
Contact Petar Bajic · 216-444-1231 · bajicp@ccf.org
Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity
Chang Gung University n=40 Chang Gung University Taoyuan
Intervention PROCEDURE: Cycling Training — Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conduct...
Eligibility Ages 18 Years
Cerebellar Stimulation for Aphasia Rehabilitation
Johns Hopkins University n=60 Johns Hopkins Hospital Baltimore, Maryland
Intervention DEVICE: Cathodal Cerebellar tDCS — 2 mA of cathodal tDCS is induced between two 5cm X 5cm saline soaked sponges where the cathode sponge is placed on the r...
Eligibility Ages 18 Years – 99 Years
Contact Rajani Sebastian, PhD · 410-502-2445 · rsebast3@jhmi.edu
A New 360° Dual-task Based Protocol for the Pre-clinical In-hospital and At-home Rehabilitation of Elderly: DUAL-Rehab
Istituto Auxologico Italiano n=90 Istituto Auxologico Italiano IRCCS Milan, MI
Intervention DEVICE: 360° media — sessions with head mounted display in hospital and sessions with tablet at home
Eligibility Ages 65 Years
Contact Elisa Pedroli, PsyD · 02 61911 2707 · e.pedroli@auxologico.it
Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.
Jan Biziel University Hospital No 2 in Bydgoszcz n=12 Department of Neurosurgery and Neurology University Hospital nr 2 Collegium Medicum Nicolaus Copernicus University Bydgoszcz
Intervention PROCEDURE: Deep brain stimulation electrode implantation with an electrode target in the dentate nucleus — The intervention will involve implantation of a directional electrode with a target in the dentate nucleus of the cerebe...
Eligibility Ages 18 Years
Contact Paweł Sokal, Ph.D. · +48600954415 · pawel.sokal@cm.umk.pl
Efficacy of Music Therapy and Digital Music Rehabilitation in Dementia
University of Helsinki n=192 University of Helsinki / Faculty of Medicine / Department of Psychology Helsinki
Intervention BEHAVIORAL: Conventional music therapy (CMT) — CMT comprises both receptive and expressive musical activities (listening and reminiscing to music, singing, and moving ...
Eligibility Ages 60 Years
Contact Anni Pitkäniemi, MA · +358503115872 · anni.pitkaniemi@helsinki.fi
Motor and Cognitive Functions in Acquired and Developmental Brain Damaged Patients
Cliniques universitaires Saint-Luc- Université Catholique de Louvain n=400 Centre Hospitalier Neurologique William Lennox Ottignies, Brabant Wallon
Intervention BEHAVIORAL: Motor, cognitive and neuropsychological assessment — Cognitive and motor testing and/or experimental cognitive or motor changes and/or cognitive or motor rehabilitation depe...
Eligibility Ages 5 Years
Contact Marie Alsamour · marie.alsamour@uclouvain.be
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
University Hospital, Bordeaux n=80 CHU de Bordeaux, Hôpital Pellegrin, Unité Neurovasculaire Bordeaux
Intervention DEVICE: Home-based cognitive training — All interventions will be carried out for both groups of participants, with either minimal or extensive cSVD. Upon enro...
Eligibility Ages 18 Years
Contact IGOR SIBON, MD, PhD · 0556795313 · igor.sibon@chu-bordeaux.fr
Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment
Uskudar University n=60 NPIstanbul Brain Hospital Istanbul
Intervention DEVICE: Active transcranial Photobiomodulation — The active intervention consists of transcranial photobiomodulation (t-PBM) delivered while the device is placed on the ...
Eligibility Ages 55 Years
Contact Shams Farhad, PhD · +905528566917 · shams.farhad@uskudar.edu.tr
Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study
Lolland Community, Denmark n=20 Frederiksberg Healthcare center and 24-hour rehabilitation Frederiksberg
Intervention OTHER: Progressive, individualized and structured exercise program — See description under Arms
Eligibility Ages 65 Years
Contact Jan Arnholtz Overgaard, MSc. · +4561121191 · jover@lolland.dk
Explore the Impacts of One Session and Multiple Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder
Chang Gung Memorial Hospital n=60 Chang Gung Memorial Hospital Taoyuan
Intervention DEVICE: Theta Burst Stimulation (TBS, an advanced variant of repetitive transcranial magnetic stimulation) — Participants will receive a single session of either iTBS or cTBS (600 pulses) targeting the right cerebellar Crus I/II....
Eligibility Ages 18 Years
Contact Hsing-Chang Ni, Ph.D · 88633281200 · alanni0918@yahoo.com.tw
Neurofeedback-Based Digital Therapeutics for the Diagnosis and Treatment of ADHD in Children.
Lei Lei, MD n=210 Changzheng Hospital, Naval Medical University Shanghai, Shanghai Municipality
Intervention DRUG: Concerta — Methylphenidate Hydrochloride Extended-Release Tablets with the following specifications: 18mg dosage, oral administrati...
Eligibility Ages 6 Years – 12 Years
Contact Yuanhao Cai, MBBS · 15001969690 · 15552283399@163.com
Intensive-neurofeedback Protocol for Children With ADHD: A Proof-of-concept Study Comparing iAPF-personalized and Standard Theta-beta-ratio Training
Bielefeld University n=40 Bielefeld University Bielefeld
Intervention BEHAVIORAL: Standard TBR-NF — Training is based on the classic Theta-Beta-Ratio protocol, where the reward frequencies are fixed for the entire traini...
Eligibility Ages 6 Years – 13 Years
Contact Luisa Himmelmeier, M.Sc. Psychology · +49 (0) 521 106 67534 · Lhimmelmeier@uni-bielefeld.de
Cognitive Rehabilitation for Veterans With PNES
VA Office of Research and Development n=47 Providence VA Medical Center, Providence, RI Providence, Rhode Island
Intervention BEHAVIORAL: Cognitive Rehabilitation And Functional Treatment (CRAFT) — Cognitive rehabilitation tailored to improve cognition and participation in daily activities for Veterans with PNES
Eligibility Ages 18 Years
Contact Madeleine R Lefkowitz, BS · (401) 127-7100 · Madeleine.Lefkowitz@va.gov
Advantage of Cerebellar Transcranial Magnetic Stimulation in Alzheimer's Diseases (ACT-AD)
Xijing Hospital n=100 Xijing Hospital of Air Force Military Medical University Xi'an, Shaanxi
Intervention DEVICE: Intermittent Theta-Burst Transcranial Magnetic Stimulation — 50Hz, stimulation intensity of 100% RMT, duration of 40s as a group of stimulation, 600 stimulation pulses, repeated sti...
Eligibility Ages 50 Years – 85 Years
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Columbia University n=144 Columbia University New York, New York
Intervention BEHAVIORAL: Home-based walking exercise — A 6-month partially supervised walking exercise program using a tapered approach.Participants will begin exercise (walki...
Eligibility Ages 55 Years
Contact Ulf G Bronas, PhD · 212-305-0750 · ub2154@cumc.columbia.edu
Cerebellar tDCS Stimulation in Children and Adult Women With Anorexia Nervosa Disorder
University of Texas Southwestern Medical Center n=15 UT Southwestern Multispecialty Psychiatry Clinic Dallas, Texas
Intervention DEVICE: anodal trans cranial direct current stimulation (tDCS) — 1 20-minute anodal tDCS stimulation
Eligibility Ages 15 Years – 30 Years, FEMALE only
Contact Haley Walker · 214-648-4617 · haley.walker@utsouthwestern.edu
Interposed Nucleus aDBS for Ataxia
University of Florida n=5 Norman Fixel Institute for Neurological Diseases Gainesville, Florida
Intervention DEVICE: Deep Brain Stimulation — This device will be surgically implanted into the interposed nucleus of the cerebellum.
Eligibility Ages 21 Years – 89 Years
Contact Julia C Gonzalez, BA · (352) 265-0111 · Julia.Gonzalez@neurology.ufl.edu