TrialFinder  /  Landscape Report CYSTIC FIBROSIS  ·  2026-09-03 Revasser  /  revasserkernel.com
Landscape Report TrialFinder
SOURCE  ClinicalTrials.gov API v2
GENERATED  2026-09-03
VERSION  v1
SAMPLE  100 of 396 studies

cystic fibrosis

The cystic fibrosis clinical trial landscape includes 396 actively recruiting trials. Semantic expansion identified 243 additional trials beyond exact-match search, representing a 158.8% discovery lift across related conditions and therapeutic approaches.

Recruiting
396
active trials
Expansion Lift
+158.8%
243 additional trials
Top Sponsor
Johns Hopkins University
3 trials
Dominant Phase
N/A
52 of 105 sampled
Pipeline Overview
Phase Distribution
NA
23
Early I
1
Phase 1
6
Phase 2
12
Phase 3
8
Phase 4
3
Other
52
Therapeutic Modalities
DRUG
46
OTHER
37
PROCEDURE
12
BEHAVIORAL
11
DIAGNOSTIC_TEST
7
BIOLOGICAL
6
DEVICE
6
GENETIC
1
Recruiting vs. Completed (2yr)
Recruiting
396
Completed
166
Competitive Landscape
Sponsor Classification
88%
8%
4%
OTHER (21)
INDUSTRY (2)
NIH (1)
Top Sponsors
SponsorTrialsClass
Johns Hopkins University3OTHER
Assistance Publique - Hôpitaux de Paris2OTHER
Philip Polgreen2OTHER
Universitaire Ziekenhuizen KU Leuven2OTHER
University of Florida2OTHER
Cairo University2OTHER
University of Chicago2OTHER
AstraZeneca2INDUSTRY
University of California, Irvine1OTHER
National Heart, Lung, and Blood Institute (NHLBI)1NIH
Insel Gruppe AG, University Hospital Bern1OTHER
Qianfoshan Hospital1OTHER
Children's Hospital Medical Center, Cincinnati1OTHER
Rhode Island Hospital1OTHER
Dana-Farber Cancer Institute1OTHER
Geographic Distribution
Top U.S. States by Trial Density
StateTrialsTop City
Florida36Miami
California25Los Angeles
Texas22Dallas
New York19New York
Maryland16Baltimore
Massachusetts15Boston
Ohio14Columbus
Colorado14Aurora
Missouri13St Louis
Pennsylvania13Philadelphia
Virginia12Fairfax
South Carolina10Charleston
Illinois10Chicago
Minnesota10Minneapolis
North Carolina9Chapel Hill
Arizona8Phoenix
Michigan8Ann Arbor
Tennessee7Nashville
Kansas7Kansas City
Nebraska7Omaha
Expansion Intelligence
+158.8%
Discovery lift — trials found by semantic expansion that exact-match search misses entirely. This is the gap competitors don't see.
2
Exact
1
Parent
3
Related
3
Comorbid
5
Therapeutic
Top Expansion Terms
  • pulmonary disease genetic Parent
  • CFTR Related
  • bronchiectasis Related
  • pancreatic insufficiency Related
  • pseudomonas aeruginosa Comorbid
  • CF-related diabetes Comorbid
  • nasal polyps Comorbid
  • CFTR modulator Therapeutic
  • elexacaftor Therapeutic
  • tezacaftor Therapeutic

These terms are curated from clinical literature — not generated by a language model. Each captures trials that use variant nomenclature for the same underlying condition or therapeutic area.

Key Findings
What This Landscape Means for cystic fibrosis
high
Standard searches miss 159% of relevant trials for cystic fibrosis — semantic expansion across related conditions and therapeutic approaches is essential for complete landscape visibility.
243 additional trials found via expansion vs 153 exact matches
high
8 Phase 3 trials indicate a maturing pipeline with near-term approval potential.
Phase 3 represents 8% of sampled trials
Next Steps
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Top Recruiting Trials
20 actively recruiting studies
Exercise in Child Health
University of California, Irvine n=240 University of California, Irvine Irvine, California
Intervention OTHER: Exercise — Cardiopulmonary Exercise Testing (CPET) will be used with Multiple Brief Exercise Bouts (MBEB) in order to obtain the ne...
Eligibility Ages 10 Years – 17 Years
Contact Peter Horvath, Ph.D. · (714) 456-8248 · phorvath@hs.uci.edu
Natural History of Bronchiectasis
National Heart, Lung, and Blood Institute (NHLBI) n=900 National Institutes of Health Clinical Center Bethesda, Maryland
Eligibility Ages 5 Years – 100 Years
Contact Chevalia J Robinson, R.N. · (301) 496-3973 · robinsoc1@nih.gov
Impact of Early Lung Physiology, Viral Infections and the Microbiota on the Development and Progression of Lung Disease in Children With Cystic Fibrosis
Insel Gruppe AG, University Hospital Bern n=500 University Children's Hospital Bern Bern
Intervention OTHER: no intervention
Eligibility Ages 0 Years – 18 Years
Contact Philipp Latzin, MD PhD · 0041 31 632 94 93 · philipp.latzin@insel.ch
Efficacy and Safety of Long-term Oral Staphylococcus Albicans Tablets in Patients With Bronchiectasis
Qianfoshan Hospital n=134 Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University Jinan, Shandong
Intervention DRUG: Staphylococcus and Neisseria Tablets — 0.3 mg/ tablet, 4 tablets each time, 3 times a day (Shandong Qilu Pharmaceutical Co., LTD.), the course of treatment was...
Eligibility Ages 18 Years
Regional Phenotyping of CF and Non-CF Bronchiectasis
Children's Hospital Medical Center, Cincinnati n=100 Penny New Cincinnati, Ohio
Intervention DRUG: Xenon — Subjects will be scanned on a commercial 3T whole-body MRI scanner equipped with high-performance gradient systems. Natu...
Eligibility Ages 5 Years – 100 Years
Contact Penny A New, BBA · 513-332-7931 · penny.new@cchmc.org
The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes
Rhode Island Hospital n=15 Boston Children's Hospital Boston, Massachusetts
Intervention BEHAVIORAL: Low Glycemic Load Diet — Food delivery service will provide a low glycemic load diet for 8 weeks, followed by a 4-month period of self-adherence ...
Eligibility Ages 18 Years – 70 Years
Contact Kevin J Scully, MB BCh BAO · 401-444-5504 · kevin_scully@brown.edu
Investigating Hereditary Risk In Thoracic Cancers (INHERIT)
Dana-Farber Cancer Institute n=500 Brigham and Women's Hospital Boston, Massachusetts
Intervention GENETIC: Data and Specimen Collection — * Provide blood and/or saliva sample * Answer short questionnaires * Consider consenting to other optional parts of the ...
Eligibility Ages 18 Years
Contact Jaclyn LoPiccolo, MD, PhD · 617-632-6036 · Jaclyn_LoPiccolo@dfci.harvard.edu
Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes
West Kazakhstan Marat Ospanov Medical University n=310 Outpatient clinics of Aktobe region, West Kazakhstan Marat Ospanov Medical University Aktobe, Aktobe
Eligibility Ages 18 Years – 74 Years
Contact Mengtay S Makashova · +77058440060 · ersultanbeknur@gmail.com
Impact of a Coordinated Dietetic-adapted Physical Activity Program on the Percentage of Lean Body Mass in Adults With Cystic Fibrosis Treated With Elexacaftor-Tezacaftor-Ivacaftor: Multicentre Randomised Controlled Trial
University Hospital, Tours n=100 Cystic Fibrosis Resource and Competence Centre, University Hospital, Angers Angers
Intervention OTHER: DIAPASOM program — A program of adapted physical activity carried out remotely by a specialist instructor, combined with personalized diete...
Eligibility Ages 18 Years
Contact Amelie GIBORY · 0247474747 · a.gibory@chu-tours.fr
Impact of Sinus Surgery on Individuals With Cystic Fibrosis
University of California, Los Angeles n=170 University of California, Los Angeles Los Angeles, California
Eligibility Ages 18 Years – 99 Years
Contact Daniel M Beswick, MD · 310-206-8457 · dbeswick@mednet.ucla.edu
NCT07616375 PHASE3
A Study to Assess the Safety of HSK31858 in Participants With Non-Cystic Fibrosis Bronchiectasis
Haisco Pharmaceutical Group Co., Ltd. n=669 Yixing People's Hospital, Yixing, Jiangxi Recruiting Yixingcun, Jiangxi
Intervention DRUG: HSK31858, tablet — HSK31858 is a novel inhibitor of DPP1 developed by Hisco Pharmaceutical and can reduce pulmonary exacerbations over a 52...
Eligibility Ages 18 Years
Contact Guan Wei Jie · 86-13826042052 · battery203@163.com
NCT06338995 PHASE3
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
Eli Lilly and Company n=510 AllerVie Clinical Research Birmingham, Alabama
Intervention DRUG: LY3650150 — Administered SC.
Eligibility Ages 12 Years
Contact Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 1-317-615-4559 · LillyTrials@Lilly.com
CRS Questionnaire Validation Project
The European Forum for Research and Education in Allergy and Airway Diseases n=1000 UCLA Santa Monica Medical Center Santa Monica, California
Eligibility Ages 18 Years
NCT06166056 PHASE1, PHASE2
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis
Chiesi Farmaceutici S.p.A. n=45 Royal Papworth Hospital NHS Foundation Trust, Cambridge Centre for Lung Infection Cambridge
Intervention DRUG: CHF6333 — CHF6333 Part I SAD; CHF6333 Part II MD.
Eligibility Ages 18 Years – 80 Years
Contact Chiesi Clinical Trial info · +39 0521 2791 · Clinicaltrials_info@chiesi.com
Epididymis Protein 4 and Pulmonary Function With Quality Improvement Protocol Among Cystic Fibrosis Patients
Ain Shams University n=35 Ain Shams university Cairo, Abbasia
Eligibility Ages 6 Years
Contact Eman Fawzy, MD · Egypt: 201011778583 · eman199358@gmail.com
Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk
CHU de Reims n=75 Chu Reims Reims
Intervention BIOLOGICAL: Blood sampling & Chest CT without injection — Anlaysis of the repartition of non-tumorous lymphocytic subpopulation in patients with untreated Chronic Lymphocytic Leu...
Eligibility Ages 18 Years
Contact Anne QUINQUENEL, Pr. · 03.26.78.74.76 · aquinquenel@chu-reims.fr
Longitudinal Cohort of Thrombosis and Hemostasis Diseases
Peking University People's Hospital n=3000 Peking University Insititute of Hematology, Peking University People's Hospital Beijing, Beijing Municipality
Contact Haixia Fu, MD · 086-01088326002 · fuhaixia_210@163.com
CF Wellness Program
Johns Hopkins University n=80 National Jewish Health Denver, Colorado
Intervention BEHAVIORAL: CF Wellness Program — Intervention modules are 1) Introduction \& Fatigue Explained, 2) Finding Balance between Activity \& Rest, 3) Physical ...
Eligibility Ages 18 Years
Contact Kristin Riekert, PhD · 4105507755 · kriekert@jhmi.edu
Cardiopulmonary Responses to 6-Minute Stepper Test in Bronchiectasis Versus Healthy Controls
Hacettepe University n=60 Hacettepe University Faculty of Physical Therapy and Rehabilitation Ankara
Intervention OTHER: No intervention; Observational study — No intervention
Eligibility Ages 18 Years
Contact Aslihan Cakmak-Onal Study Principal Investigator, PhD, PT · +903123051576 · aslihancakmak90@gmail.com
A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up
National Institute of Allergy and Infectious Diseases (NIAID) n=10000 National Institutes of Health Clinical Center Bethesda, Maryland
Eligibility Ages 3 Years – 100 Years
Contact Hye Jeong C Bolan, R.N. · (301) 594-1233 · NIAIDMADREP@NIH.GOV