TrialFinder  /  Landscape Report DEPRESSION  ·  2026-09-03 Revasser  /  revasserkernel.com
Landscape Report TrialFinder
SOURCE  ClinicalTrials.gov API v2
GENERATED  2026-09-03
VERSION  v1
SAMPLE  100 of 4821 studies

depression

The depression clinical trial landscape includes 4821 actively recruiting trials. Semantic expansion identified 3372 additional trials beyond exact-match search, representing a 232.7% discovery lift across related conditions and therapeutic approaches.

Recruiting
4821
active trials
Expansion Lift
+232.7%
3372 additional trials
Top Sponsor
Massachusetts General Hospital
3 trials
Dominant Phase
NA
62 of 101 sampled
Pipeline Overview
Phase Distribution
NA
62
Early I
1
Phase 1
5
Phase 2
9
Phase 3
2
Phase 4
3
Other
19
Therapeutic Modalities
BEHAVIORAL
52
OTHER
43
DEVICE
28
DRUG
20
PROCEDURE
5
DIAGNOSTIC_TEST
4
DIETARY_SUPPLEMENT
2
BIOLOGICAL
1
Recruiting vs. Completed (2yr)
Recruiting
4821
Completed
3570
Competitive Landscape
Sponsor Classification
96%
4%
OTHER (25)
INDUSTRY (1)
Top Sponsors
SponsorTrialsClass
Massachusetts General Hospital3OTHER
University of Manitoba2OTHER
Weill Medical College of Cornell University2OTHER
University of Washington2OTHER
University of Roehampton2OTHER
Riphah International University2OTHER
Washington University School of Medicine2OTHER
Medical University of South Carolina2OTHER
Baylor College of Medicine2OTHER
Wake Forest University Health Sciences2OTHER
Shanghai Geriatric Medical Center1OTHER
University Hospital, Montpellier1OTHER
Enalare Therapeutics Inc.1INDUSTRY
Centre Hospitalier Henri Laborit1OTHER
Region Örebro County1OTHER
Geographic Distribution
Top U.S. States by Trial Density
StateTrialsTop City
Florida12Miami
Texas10Houston
California10Los Angeles
Massachusetts10Boston
Pennsylvania8Philadelphia
New York6New York
New Jersey6Eatontown
North Carolina6Durham
Washington5Seattle
Connecticut5New Haven
Colorado3Denver
Maryland3Baltimore
Minnesota3Minneapolis
South Carolina3Charleston
Arizona2Phoenix
Iowa2Iowa City
Michigan2Ann Arbor
Ohio2Cincinnati
Tennessee2Memphis
Utah2Salt Lake City
Expansion Intelligence
+232.7%
Discovery lift — trials found by semantic expansion that exact-match search misses entirely. This is the gap competitors don't see.
4
Exact
2
Parent
6
Related
5
Comorbid
7
Therapeutic
Top Expansion Terms
  • mood disorder Parent
  • affective disorder Parent
  • treatment-resistant depression Related
  • persistent depressive disorder Related
  • dysthymia Related
  • seasonal affective disorder Related
  • postpartum depression Related
  • peripartum depression Related
  • anxiety Comorbid
  • insomnia Comorbid

These terms are curated from clinical literature — not generated by a language model. Each captures trials that use variant nomenclature for the same underlying condition or therapeutic area.

Key Findings
What This Landscape Means for depression
high
Standard searches miss 233% of relevant trials for depression — semantic expansion across related conditions and therapeutic approaches is essential for complete landscape visibility.
3372 additional trials found via expansion vs 1449 exact matches
high
Phase 2 volume (9) significantly exceeds Phase 3 (2), indicating a pipeline bottleneck — most candidates are 2-4 years from potential approval.
Phase 2/Phase 3 ratio: 4.5x
Next Steps
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Top Recruiting Trials
20 actively recruiting studies
Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study
Shanghai Geriatric Medical Center n=634 Shanghai Geriatric Medical Center Shanghai
Eligibility Ages 65 Years
Contact Hao Fang · 02164175590 · drfanghao@163.com
Feasibility of a Multimodal Virtual Reality Intervention to Reduce Preoperative Anxiety in Cancer Surgery Patients
University of Manitoba n=20 Health Sciences Centre Winnipeg, Manitoba
Intervention DEVICE: Virtual Reality — The VR simulation involves the experience of prepping, waiting, receiving, and recovering from surgery at a large tertia...
Eligibility Ages 18 Years
Contact Cassidy Santos, BA (Hons.) · 204-787-7424 · csantos17@hsc.mb.ca
Conceptualizing Borderline Personality Disorder as a Relationship Use Disorder
University Hospital, Montpellier n=194 CHU Montpellier Montpellier
Intervention OTHER: Relationship-use questionnaire — Questionnaire adapted from the 'Substance Use Disorders' section of the DSM-5: Disorder related to the use of close rela...
Eligibility Ages 18 Years – 45 Years
Mind-Body Skills Group for Graduate Students
Weill Medical College of Cornell University n=60 Weill Cornell Medical College White Plains, New York
Intervention BEHAVIORAL: Integrative-Mind-Body Skills Group — Integrative-Mind-Body Skills Group (I-MBS-G) is an 8-week group that teaches skills to build inner resources for effecti...
Eligibility Ages 18 Years
Contact Suza C Scalora, PhD · 917-209-5311 · sus9128@med.cornell.edu
NCT06967259 PHASE1
ENA-001 for Opioid Induced Respiratory Depression
Enalare Therapeutics Inc. n=36 South Florida Research Phase I-IV Miami, Florida
Intervention DRUG: ENA-001 — Concentration for ENA-001 IV formulation is 10 mg/mL. Concentration for ENA 001 IM formulation is 30 mg/mL.
Eligibility Ages 18 Years – 55 Years
Contact Mathews · 908-947-5491 · jmathews@enalare.com
Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation
Centre Hospitalier Henri Laborit n=50 Centre Hospitalier Nord-Deux-Sèvres Faye-l'Abbesse
Intervention DEVICE: Transcranial direct current stimulation — 1 stimulation per day during 15 days.
Eligibility Ages 18 Years
Contact Ghina Harika-Germaneau · 05.16.52.61.18 · ghina.harika-germaneau@ch-poitiers.fr
NCT04057378 PHASE4
Optimal Electrical Stimulus During Electroconvulsive Therapy
Region Örebro County n=800 University hospital Örebro Örebro
Intervention DEVICE: Electroconvulsive therapy — Electrically induced convulsion under anesthesia
Eligibility Ages 18 Years
Contact Axel Nordenskjöld, MD, PhD · +46196021000 · axel.nordenskjold@regionorebrolan.se
Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
GrayMatters Health Ltd. n=170 Butler Hospital Providence, Rhode Island
Intervention DEVICE: Prism Training — Participants will complete 20 Prism training sessions. The Prism training sessions take place twice a week over a 10-wee...
Eligibility Ages 22 Years – 75 Years
Contact Adar Shani, MSc · +972-54-2347770 · adar@graymatters-health.com
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Massachusetts General Hospital n=8000 Barrow Neurological Institute Phoenix, Arizona
Eligibility Ages 18 Years
Contact James Meschia, MD · 904-953-6515 · meschia.james@mayo.edu
CIH Stepped Care for Co-occurring Chronic Pain and PTSD
University of Washington n=60 University of Washington Seattle, Washington
Intervention BEHAVIORAL: CIH Stepped Care — CIH Stepped Care is a stepped approach to care delivered by a health coach (e.g., psychologist-in-training or clinical s...
Eligibility Ages 18 Years
Contact David Reed, PhD · 206-543-3752 · davider2@uw.edu
Weighted Blanket Use to Reduce Anxiety in Oncology Patients
Ohio State University Comprehensive Cancer Center n=114 Ohio State University Comprehensive Cancer Center Columbus, Ohio
Intervention OTHER: Best Practice — Use a regular blanket
Eligibility Ages 18 Years
Contact The Ohio State Comprehensive Cancer Center · 800-293-5066 · OSUCCCClinicaltrials@osumc.edu
Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain
Stanford University n=110 1070 Arastradero Rd Palo Alto, California
Intervention OTHER: Usual Care — Participants who are randomized to the Usual Care group (waitlist for cross-over to ER) will be instructed to continue w...
Eligibility Ages 18 Years
Contact Lorena Contreras · 650-497-6141 · spanishempoweredrelief@stanford.edu
Virtual Reality Versus Intravenous Dexmedetomidine on Maternal Anxiety, Stress, Hemodynamics, and Neonatal Outcomes During Cesarean Section
Benha University n=52 Benha University Banhā, Benha
Intervention DRUG: Dexmedetomidine — Following confirmation of adequate spinal anesthesia, dexmedetomidine will be administered as an intravenous infusion of...
Eligibility Ages 18 Years, FEMALE only
Contact Emad M Sayed, MBBCH · 00201111710428 · dr.emad.mohamedsayed@gmail.com
A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults
Weill Medical College of Cornell University n=80 University of Michigan Ann Arbor, Michigan
Intervention BEHAVIORAL: Strengthening COnnections to Overcome Pain (SCOOP) — Each week for 7 weeks, SCOOP intervention group participants will watch a brief video on the study website teaching a pa...
Eligibility Ages 60 Years
Contact Mary R. Janevic, PhD · 734-647-3194 · mjanevic@umich.edu
Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work
University of Roehampton n=50 University of Roehampton London
Intervention BEHAVIORAL: Remi, AI avatar-led cognitive behavioural therapy intervention — The InsideOut AI programme for low mood is based on principles of Cognitive Behavioral Therapy (CBT), adapted into a sel...
Eligibility Ages 18 Years
Contact Laura M Vowels, PhD · +447858024296 · laura.vowels@roehampton.ac.uk
Psychiatric Outcomes of Unruptured Intracranial Aneurysms (POUIA)
Montefiore Medical Center n=120 Montefiore Medical Center The Bronx, New York
Intervention PROCEDURE: Clipping — Microsurgical clipping of intracranial aneurysms involves craniotomy to access the brain, locating the aneurysm, and pla...
Eligibility Ages 18 Years – 75 Years
Contact Muhammed Amir Essibayi, MD · 718-920-7498 · muhammedamir.essibayi@einsteinmed.edu
Lf-rTMS Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea
The First Affiliated Hospital of Soochow University n=42 The First Affiliated Hospital of Soochow University Suzhou, Jiangsu
Intervention DEVICE: Repetitive Transcranial Magnetic Stimulation — A figure-of-eight coil is used to apply active low-frequency (1 Hz) rTMS to the corresponding representation area of the...
Eligibility Ages 18 Years – 75 Years
Contact Ruixia Weng, Dr. · 15206214921 · wengruixia@suda.edu.cn
NCT06619613 PHASE1
A Study of CM383 in Patients With Alzheimer's Disease Related Mild Cognitive Impairment and Mild Alzheimer's Disease
Keymed Biosciences Co.Ltd n=48 The First Affiliated Hospital of University of Science and Technology of China Hefei
Intervention BIOLOGICAL: Alzheimer Disease (AD) — CM383 injection
Eligibility Ages 50 Years – 85 Years
Contact Qian Jia · 86 + 02888610620 · qianjia@keymedbio.com
Evaluating the Effectiveness of Implementation Intentions to Strengthen Approach-avoidance Training
Clinique de la Mitterie n=112 Clinique la Mitterie Lille
Intervention BEHAVIORAL: Approach Bias Modification with Implementation Intentions — Participants in each experimental condition will perform different variants of the Approach-Avoidance Task (i.e., a task...
Contact Nicolas KACZMAREK · +33320223303 · nkaczmarek@clinique-mitterie.com
Maze Balance Board Training Effects on Mobility and Motor Skills in Cognitively Impaired Children
Riphah International University n=22 Imran Amjad, PhD Lahore, Punjab Province
Intervention OTHER: Maze Balance Board traing — The experimental group (n=11) will receive Maze Balance Board Training in a one-on-one setting, conducted three times pe...
Eligibility Ages 6 Years – 10 Years
Contact Imran Amjad, MS-PT · 9233224390125 · imran.amjad@riphah.edu.pk