TrialFinder  /  Landscape Report PTSD  ·  2026-07-18 Revasser  /  revasserkernel.com
Landscape Report TrialFinder
SOURCE  ClinicalTrials.gov API v2
GENERATED  2026-07-18
VERSION  v1
SAMPLE  100 of 4335 studies

ptsd

The ptsd clinical trial landscape includes 4335 actively recruiting trials. Semantic expansion identified 3925 additional trials beyond exact-match search, representing a 957.3% discovery lift across related conditions and therapeutic approaches.

Recruiting
4335
active trials
Expansion Lift
+957.3%
3925 additional trials
Top Sponsor
VA Office of Research and Development
4 trials
Dominant Phase
NA
71 of 102 sampled
Pipeline Overview
Phase Distribution
NA
71
Phase 1
4
Phase 2
10
Phase 3
1
Phase 4
1
Other
15
Therapeutic Modalities
BEHAVIORAL
65
OTHER
34
DEVICE
28
DRUG
24
PROCEDURE
5
DIETARY_SUPPLEMENT
4
DIAGNOSTIC_TEST
2
COMBINATION_PRODUCT
2
Recruiting vs. Completed (2yr)
Recruiting
4335
Completed
3109
Competitive Landscape
Sponsor Classification
13%
80%
7%
FED (4)
OTHER (24)
OTHER_GOV (2)
Top Sponsors
SponsorTrialsClass
VA Office of Research and Development4FED
Medical University of South Carolina3OTHER
Johns Hopkins University3OTHER
The Hong Kong Polytechnic University2OTHER
University of Pittsburgh2OTHER
University of Washington2OTHER
Indiana University2OTHER
Region Stockholm2OTHER_GOV
Ohio State University2OTHER
Mayo Clinic2OTHER
Milton S. Hershey Medical Center2OTHER
University Hospital, Basel, Switzerland1OTHER
Universitaire Ziekenhuizen KU Leuven1OTHER
University of Edinburgh1OTHER
Laureate Institute for Brain Research, Inc.1OTHER
Geographic Distribution
Top U.S. States by Trial Density
StateTrialsTop City
Pennsylvania6Pittsburgh
Ohio5Columbus
South Carolina4Charleston
Texas4Houston
Massachusetts4Boston
Minnesota3Rochester
Maryland3Baltimore
Michigan2Ann Arbor
Washington2Seattle
Indiana2Indianapolis
New York2The Bronx
California2Palo Alto
Florida2Gainesville
Oklahoma1Tulsa
Illinois1Chicago
New Mexico1Albuquerque
Iowa1Iowa City
Wisconsin1Madison
Rhode Island1Providence
Alabama1Birmingham
Expansion Intelligence
+957.3%
Discovery lift — trials found by semantic expansion that exact-match search misses entirely. This is the gap competitors don't see.
3
Exact
3
Parent
3
Related
4
Comorbid
5
Therapeutic
Top Expansion Terms
  • anxiety disorder Parent
  • stress disorder Parent
  • trauma-related disorder Parent
  • complex PTSD Related
  • acute stress disorder Related
  • combat stress Related
  • depression Comorbid
  • substance use disorder Comorbid
  • insomnia Comorbid
  • traumatic brain injury Comorbid

These terms are curated from clinical literature — not generated by a language model. Each captures trials that use variant nomenclature for the same underlying condition or therapeutic area.

Key Findings
What This Landscape Means for ptsd
high
Standard searches miss 957% of relevant trials for ptsd — semantic expansion across related conditions and therapeutic approaches is essential for complete landscape visibility.
3925 additional trials found via expansion vs 410 exact matches
high
Phase 2 volume (10) significantly exceeds Phase 3 (1), indicating a pipeline bottleneck — most candidates are 2-4 years from potential approval.
Phase 2/Phase 3 ratio: 10.0x
Next Steps
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Top Recruiting Trials
20 actively recruiting studies
NCT05883540 PHASE2
Lysergic Acid Diethylamide (LSD) in Palliative Care
University Hospital, Basel, Switzerland n=60 University Hospital Basel, Division of Clinical Pharmacology and Toxicology Basel
Intervention DRUG: Lysergic Acid Diethylamide Tartrate — 25 μg p.o.
Eligibility Ages 22 Years
Contact Yasmin Schmid, PD Dr. med. · : +41 61 328 68 47 · yasmin.schmid@usb.ch
Web-based Single-session Intervention of Mindset for Improving Pre-practicum Anxiety and Coping
The Hong Kong Polytechnic University n=117 The Hong Kong Polytechnic University Hong Kong
Intervention BEHAVIORAL: Web-based Single-session Intervention of Mindset on Intelligence, Failure, and Emotion (We-SMILE) — This study will be a two-arm randomised controlled trial to examine the efficacy of the We-SMILE for pre-practicum socia...
Eligibility Ages 18 Years – 24 Years
Contact Shimin Zhu, PhD · +852 2766 5787 · jasmine.zhu@polyu.edu.hk
Changing Tactics? Optimizing ECT in Difficult-to-treat Depression
Universitaire Ziekenhuizen KU Leuven n=196 UPC Kortenberg Kortenberg
Intervention DEVICE: switch to BT electrode position — use of different electrode positions of ECT device
Eligibility Ages 18 Years
Contact Pascal Sienaert, MD,PhD · +322 758 05 11 · pascal.sienaert@upckuleuven.be
Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients
University of Edinburgh n=100 St John's Hospital Livingston, West Lothian
Intervention OTHER: Questionnaires, rating scales, & review of notes — Observational - questionnaires, rating scales, \& review of notes
Eligibility Ages 18 Years – 65 Years
Contact David Hayward · 01506 523000 · david.hayward@nhslothian.scot.nhs.uk
Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
Laureate Institute for Brain Research, Inc. n=140 Laureate Institute for Brain Research Tulsa, Oklahoma
Intervention OTHER: Low-intensity focused ultrasound — 80-second stimulus with an estimated tissue ISSPA=2.26 W/cm2, with (sham) or without (verum) interposition of Sorbothane...
Eligibility Ages 18 Years – 65 Years
Contact Salvador M Guinjoan, MD, PhD · 918-502-5119 · sguinjoan@laureateinstitute.org
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
University of Illinois at Chicago n=146 University of Illinois at Chicago Chicago, Illinois
Intervention BEHAVIORAL: POWER-MS — The POWER-MS intervention includes both aerobic exercise and resistance exercise: Aerobic Exercise: The goal of the ae...
Eligibility Ages 18 Years – 64 Years
Contact Robert W Motl, PhD · 205-975-1306 · robmotl@uic.edu
Mobile Platform for Optimizing Wellness and Engagement in Recovery
University of Michigan n=50 University of Michigan Ann Arbor, Michigan
Intervention BEHAVIORAL: Digital Contingency Management Intervention Arm — Participants will use a version of the app for 6-months. Participants in this group may earn rewards for completing reco...
Eligibility Ages 19 Years – 63 Years
Contact Haley Stevens · 734-764-9910 · hsteve@med.umich.edu
Relationship Between Central Sensitization and Clinical Features in Plantar Fasciitis
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey n=128 Sultan Abdulhamid Han Training and Research Hospital Istanbul
Intervention OTHER: Pressure Pain Threshold Assessment — Pressure pain threshold measurements will be performed using a pressure algometer to assess pain sensitivity.
Eligibility Ages 18 Years – 65 Years
Contact Feyza Nur Yücel, Assoc. Prof. · 2165422000 · dr.fny28@gmail.com
Effect of Neuromuscular Stimulation and Mindfulness Exercise in Patients With Stroke
Cairo University n=60 Faculty of Physical Therapy Cairo, Dokki
Intervention OTHER: neuromuscular stimulation and mindfulness — Receive neuromuscular stimulation and mindfulness breathing; the experimental group participants will receive neuromuscu...
Eligibility Ages 50 Years – 65 Years
Contact marwa elsayed, PhD · 0201156033818 · marwa.elsaid@cu.edu.eg
Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study
Jing Han n=120 Tang-Du Hospital,Department of Cardiology Xi'an, Shaanxi
Intervention DEVICE: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Intervention — Transcutaneous auricular vagus nerve stimulation (taVNS) is delivered to the cymba conchae of the ear using a dedicated ...
Eligibility Ages 18 Years
Contact jing Han, Pursuing Master's Degree · 8618506576253 · 710694996@qq.com
NCT05885542 PHASE1, PHASE2
SCORE Emerging Adult Cannabis Use & Stress
Medical University of South Carolina n=148 Medical University of South Carolina Charleston, South Carolina
Intervention DRUG: Cannabidiol oral solution — Double-blind cannabidiol oral solution 800 mg administered once
Eligibility Ages 18 Years – 25 Years
Contact Kevin Branson · 843-792-0493 · bransonk@musc.edu
Process-based Therapy for Difficult-to-treat Anxiety Disorders and Depression
Goethe University n=80 JWGUniversity Frankfurt am Main, Hesse
Intervention OTHER: Process-based Cognitive Behavioral Therapy (PBT) — PBT (20 sessions), intervention planning based on the use of EMA data, feedback of dynamic network analysis and matching...
Eligibility Ages 18 Years – 65 Years
Contact Ulrich Stangier, PhD · 049 1707339293 · stangier@psych.uni-frankfurt.de
Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients
University of Pittsburgh n=424 UNM Albuquerque, New Mexico
Intervention BEHAVIORAL: Technology Assisted Stepped Collaborative Care — The TĀCcare 2.0 intervention will provide pharmacotherapy recommendations and/or CBT for pain, fatigue and depression. A...
Eligibility Ages 18 Years
Contact Manisha Jhamb, MD, MPH · 412-647-7062 · jhambm@upmc.edu
Investigating the Efficacy and Mechanisms of Individualized tACS Targeting Anhedonia in Late-Life Depression
Jie Li n=80 Tianjin Anding Hospital Tianjin, Tianjin Municipality
Intervention DEVICE: Transcranial Alternating Current Stimulation (tACS) — divided into a real-stimulus group and a sham-stimulus group
Eligibility Ages 60 Years
Contact Daliang Sun Da liang Sun, Doctor · +86 88188876 · 474929588@qq.com
NCT07546266 PHASE1
Yoga for Black and Brown Women Who Have Experienced Abuse From an Intimate Partner
The University of Akron n=40 the University of Akron Akron, Ohio
Intervention BEHAVIORAL: Culturally-Tailored, Trauma-Informed Yoga (CT-TIY) — Participants will be offered 15 weekly yoga classes and encouraged to attend at least 10 classes. Each class will be 75 ...
Eligibility Ages 18 Years, FEMALE only
Contact Dawn Johnson, Ph.D. · 330-972-7111 · johnsod@uakron.edu
Effects of Virtual Reality Education on Anxiety and Learning in Patients Undergoing Urolithiasis Surgery
Wei-Lin, Huang n=90 Keelung Chang Gung Memorial Hospital Keelung
Intervention BEHAVIORAL: VR Education — Participants receive standard virtual reality-based preoperative education before urolithiasis surgery. The VR program i...
Eligibility Ages 18 Years
Contact wellin Huang, RN, MSN Student · +886 953713535 · hwl0111@gmail.com
Genetic Risk Factor for Heat Stroke
University of Iowa n=200 University of Iowa Health Care Iowa City, Iowa
Intervention PROCEDURE: Heat Challenge — Participants will be asked to arrive well-hydrated and to refrain from exercise, alcohol, caffeine, and smoking for 24 h...
Eligibility Ages 18 Years – 60 Years
Contact Aaron Miller, PhD · (319) 335-3053 · aaron-miller@uiowa.edu
Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia
National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland n=75 Rehabilitation Clinic, National Institute of Geriatrics, Rheumatology and Rehabilitation (NIGRiR) Warsaw, Masovian Voivodeship
Intervention OTHER: Physical Training Program — Structured physical training using Zebris diagnostic treadmill and Alfa balance platform, performed under physiotherapis...
Eligibility Ages 20 Years – 80 Years
Contact Filip Królikowski, MSc, Physiotherapist · 226709161 · Filip.krolikowski@spartanska.pl
Real-time eCounselling for Nicotine Addiction
Overcome n=60 Key contact Leicester, Midlands
Intervention BEHAVIORAL: CBT-MI — CBT-MI combines elements from Cognitive Behavioural Therapy and Motivational Interviewing in treating nicotine addiction...
Eligibility Ages 18 Years – 65 Years
Contact Helen Hayward, BSc · 447423967654 · operations_manager@overcome.org.uk
PTSD Treatment for Incarcerated Men and Women: AV
University of Wisconsin, Madison n=900 Psychiatric Institute and Clinic Madison, Wisconsin
Intervention BEHAVIORAL: Cognitive Processing Therapy — CPT: a type of cognitive behavioral therapy recommended for the treatment of PTSD. Delivered in 8 - 12, 90-minute sessio...
Eligibility Ages 18 Years
Contact Michael R Koenigs, PhD · (608) 263-1679 · mrkoenigs@wisc.edu