TrialFinder  /  Landscape Report TREATMENT-RESISTANT DEPRESSION  ·  2026-10-26 Revasser  /  revasserkernel.com
Landscape Report TrialFinder
SOURCE  ClinicalTrials.gov API v2
GENERATED  2026-10-26
VERSION  v1
SAMPLE  100 of 3884 studies

treatment-resistant depression

The treatment-resistant depression clinical trial landscape includes 3884 actively recruiting trials. Semantic expansion identified 3755 additional trials beyond exact-match search, representing a 2910.9% discovery lift across related conditions and therapeutic approaches.

Recruiting
3884
active trials
Expansion Lift
+2910.9%
3755 additional trials
Top Sponsor
Stanford University
4 trials
Dominant Phase
NA
73 of 101 sampled
Pipeline Overview
Phase Distribution
NA
73
Early I
1
Phase 1
2
Phase 2
7
Phase 3
3
Phase 4
4
Other
11
Therapeutic Modalities
BEHAVIORAL
55
DEVICE
40
OTHER
39
DRUG
27
PROCEDURE
4
DIAGNOSTIC_TEST
4
COMBINATION_PRODUCT
3
DIETARY_SUPPLEMENT
3
Recruiting vs. Completed (2yr)
Recruiting
3884
Completed
3204
Competitive Landscape
Sponsor Classification
90%
10%
OTHER (26)
FED (3)
Top Sponsors
SponsorTrialsClass
Stanford University4OTHER
VA Office of Research and Development3FED
Chinese University of Hong Kong3OTHER
Medical University of South Carolina3OTHER
University of California, Los Angeles2OTHER
Cairo University2OTHER
University of Pennsylvania2OTHER
Massachusetts General Hospital2OTHER
Weill Medical College of Cornell University2OTHER
Elisabetta Brigo1OTHER
Florida State University1OTHER
University Hospital, Montpellier1OTHER
St. Joseph's Healthcare Hamilton1OTHER
University of Regina1OTHER
Zi-Xiao Li1OTHER
Geographic Distribution
Top U.S. States by Trial Density
StateTrialsTop City
California17Los Angeles
Florida10Miami
Texas5Houston
South Carolina5Charleston
Maryland4Baltimore
Pennsylvania3Philadelphia
New York3New York
Massachusetts3Boston
Georgia2Augusta
Illinois2Naperville
Ohio2Independence
Virginia2Richmond
Colorado2Denver
Indiana1Indianapolis
Missouri1Columbia
Idaho1Boise
Arkansas1Bryant
Nebraska1Omaha
Michigan1Royal Oak
Wisconsin1Madison
Expansion Intelligence
+2910.9%
Discovery lift — trials found by semantic expansion that exact-match search misses entirely. This is the gap competitors don't see.
3
Exact
2
Parent
3
Related
4
Comorbid
7
Therapeutic
Top Expansion Terms
  • major depressive disorder Parent
  • mood disorder Parent
  • depression Related
  • chronic depression Related
  • persistent depressive disorder Related
  • anxiety Comorbid
  • suicidal ideation Comorbid
  • chronic pain Comorbid
  • insomnia Comorbid
  • ketamine Therapeutic

These terms are curated from clinical literature — not generated by a language model. Each captures trials that use variant nomenclature for the same underlying condition or therapeutic area.

Key Findings
What This Landscape Means for treatment-resistant depression
high
Standard searches miss 2911% of relevant trials for treatment-resistant depression — semantic expansion across related conditions and therapeutic approaches is essential for complete landscape visibility.
3755 additional trials found via expansion vs 129 exact matches
high
Phase 2 volume (7) significantly exceeds Phase 3 (3), indicating a pipeline bottleneck — most candidates are 2-4 years from potential approval.
Phase 2/Phase 3 ratio: 2.3x
Next Steps
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Top Recruiting Trials
20 actively recruiting studies
Barefoot Walking VS Standardised Conservative Care for Plantar Fasciopathy
Elisabetta Brigo n=74 South East Technological University Carlow, Carlow County
Intervention BEHAVIORAL: Barefoot Walking Programme — A structured 12-week progressive home-based barefoot walking programme on grass for adults with plantar fasciopathy. Par...
Eligibility Ages 18 Years – 70 Years
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Florida State University n=72 Florida State University Tallahassee, Florida
Intervention DEVICE: Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4 — Stimulation will be delivered via the Neurocare Direct Current Stimulator Multi-Channel 4, an investigational electrical...
Eligibility Ages 18 Years – 65 Years
Contact Justin M Riddle, PhD · 850-645-2389 · jriddle@fsu.edu
NCT05681572 PHASE3
Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia
University Hospital, Montpellier n=1000 Uhmontpellier Montpellier, Montpellier
Intervention DRUG: Midazolam — 45 minutes before entering the operating room, patient receives the oral treatment according to their randomization arm,...
Eligibility Ages 7 Years – 18 Years
Contact Sophie BRINGUIER, PHD · 0467338661 · s-bringuierbranchereau@chu-montpellier.fr
Psychological and Physiological Impact of a Mindfulness-based Intervention on Anxiety Disorders During the Postpartum Period
St. Joseph's Healthcare Hamilton n=50 Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton Hamilton, Ontario
Intervention BEHAVIORAL: 4-week mindfulness-based intervention — This is the first mindfulness-based intervention specifically designed for postpartum mothers and birthing parents with ...
Eligibility Ages 18 Years, FEMALE only
Contact Sheryl M Green, Ph.D., C.Psych · 905-522-1155 · sgreen@stjosham.on.ca
The PSP Sleep Course: An Online Sleep Intervention for Public Safety Personnel With Self-reported Sleep Difficulties.
University of Regina n=60 University of Regina Regina, Saskatchewan
Intervention BEHAVIORAL: Sleep Course — The Sleep Course was previously developed and evaluated in Australia and has since been tailored to Canadian public safe...
Eligibility Ages 18 Years
Contact Heather D Hadjistavropoulos, PhD · 306-585-5133 · heather.hadjistavropoulos@uregina.ca
HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke
Zi-Xiao Li n=70 Beijing Tiantan hospital Beijing
Intervention DEVICE: iTBS group — iTBS on the contralesional cerebellum, twice a day for seven days
Eligibility Ages 18 Years
Contact Weili Jia, Dr. · +86 13120207987 · jiawl1994@163.com
Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:
Centre Hospitalier Universitaire, Amiens n=354 CHU Amiens-Picardie Amiens
Intervention OTHER: standard institutional perioperative management — standard institutional perioperative management
Eligibility Ages 18 Years
Contact Paul Tarpin, MD · 33+3.22.08.79.80 · Tarpin.paul@chu-amiens.fr
NCT07294092 EARLY_PHASE1
Ketamine and Propofol NeuroImaging
Keith M Vogt n=60 University of Pittsburgh Pittsburgh, Pennsylvania
Intervention DRUG: Propofol — Subjects will receive an intravenous infusion of this drug, during portions of the study.
Eligibility Ages 18 Years – 59 Years
Contact Keith M Vogt, MD, PhD · 4126473147 · kev18@pitt.edu
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Chulalongkorn University n=100 King Chulalongkorn Memorial hospital, The Thai Red Cross Society Bangkok, Pathumwan
Intervention DEVICE: Personalized rTMS — Personalized repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise
Eligibility Ages 18 Years – 80 Years
Contact Jakkrit Amornvit, MD · Thailand: 88-951-9195 · jakkrit.a@chula.ac.th
Personalized AI-Driven Models in Cognitive Behavioral Therapy for Anxiety
University of Southern California n=140 University of Southern California Los Angeles, California
Intervention BEHAVIORAL: Explicit CBT SAR Personalization for 6 weeks — College student participants with clinically elevated anxiety will engage in 6 weeks of in-home CBT daily exercises with...
Eligibility Ages 18 Years
Options for Pain Management Using Nonpharmacological Strategies
VA Office of Research and Development n=296 Richard L. Roudebush VA Medical Center, Indianapolis, IN Indianapolis, Indiana
Intervention BEHAVIORAL: Options for Pain Management using Non-medication Strategies — The purpose of this study is to help Veterans learn about different ways they can manage chronic pain that do not involv...
Eligibility Ages 18 Years
Contact Marianne S Matthias, PhD MS BA · (520) 626-6154 · msmatthias@arizona.edu
NCT06511011 PHASE2
Chinese Medicine in Treating Insomnia
Chinese University of Hong Kong n=76 Hong Kong Institute of Integrative Medicine Shatin
Intervention DRUG: Modified Suan ZaoRen Tang-TianWang BuXin Dan — Chinese medicine granules for 6 weeks
Eligibility Ages 18 Years – 65 Years
Contact Zhixiu Lin · 39436347 · linzx@cuhk.edu.hk
In-patient SCC TMS
University of California, Los Angeles n=30 UCLA TMS Service and Research Service Los Angeles, California
Intervention DEVICE: Open-label TMS — Customized, Open-Label Transcranial Magnetic Stimulation
Eligibility Ages 18 Years – 65 Years
Contact Nikita Vincecruz, BS · 310-825-4781 · nvincecruz@mednet.ucla.edu
Continuous Theta Burst Stimulation for Generalized Anxiety Disorder
Military Hospital 175 n=40 Military Hospital 175 Ho Chi Minh City
Intervention DEVICE: Continuous Theta Burst Stimulation of the Right Posterior Parietal Cortex — Continuous theta burst stimulation (cTBS) is delivered to the right posterior parietal cortex (R-PPC), identified at the...
Eligibility Ages 18 Years – 65 Years
Contact Dang Minh Ly, MD · +84359999741 · drminhdang@outlook.com
rTMS for Depression in Young Adults With Autism
Centre for Addiction and Mental Health n=80 Centre for Addiction and Mental Health Toronto, Ontario
Intervention DEVICE: Active Bilateral Theta Burst Stimulation — A total of 30 active BL-TBS sessions. Stimulation will begin with right DLPFC (cTBS) followed by left DLPFC (iTBS)
Eligibility Ages 16 Years – 35 Years
Contact Viviane Grassmann, PhD · 416-535-8501 · AutismTMS@camh.ca
Changes in Etomidate Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
Beijing Tiantan Hospital n=840 Beijing Tiantan Hospital Beijing, Beijing Municipality
Intervention OTHER: No interventions, it is a observational study — No interventions, this study is to compare the dosage requirement of etomidate under intravenous anesthesia between inso...
Eligibility Ages 18 Years – 64 Years
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development n=200 San Francisco VA Medical Center, San Francisco, CA San Francisco, California
Intervention BEHAVIORAL: Brief Behavioral Treatment for Insomnia (BBTI) — Participants in this arm will receive 4 sessions (30-60 minutes) of a brief behavioral treatment for insomnia called BBT...
Eligibility Ages 18 Years – 75 Years
Contact Shira Maguen, PhD · (415) 221-4810 · shira.maguen@va.gov
Respiratory Exercises Versus Deep Neck Flexor Training in Chronic Mechanical Neck Pain
Cairo University n=66 Taheel center for physiotherapy Zagazig
Intervention OTHER: Respiratoty exercises — respiratory exercises in form of diaphragmatic breathing \& respiratory muscle stretch gymnastics plus conventional prog...
Eligibility Ages 18 Years – 35 Years
Contact ola ismail ibrahim, M.Sc. · +201008283364 · olaismailibrahim@gmail.com
Telehealth Behavioral Activation for Teens
Baylor College of Medicine n=250 Baylor College of Medicine Houston, Texas
Intervention OTHER: Behavioral Activation — All participants will undergo behavioral activation treatment for 8-10 weeks
Eligibility Ages 12 Years – 18 Years
Contact Emily Bivins, B.S. · 713-798-1709 · emily.bivins@bcm.edu
A Prospective Registry of Vaginal Photobiomodulation for Chronic Pelvic Pain.
SoLa Pelvic Therapy n=1000 Zipper Urogynecology Associates Melbourne, Florida
Intervention DEVICE: SoLá Pelvic Therapy (SPT) — SoLá Pelvic Therapy (SPT) is administered as part of routine clinical care to patients with chronic pelvic pain. Treatme...
Eligibility Ages 18 Years, FEMALE only
Contact Georgine Lamvu, MD, MPH · 407-461-1189 · georgine@solapelvictherapy.com